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Institute of Tissue Regeneration Engineering
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BULLENTIN
Medical Research Center
Medical Research Center
Institute of Tissue Regeneration Engineering
The Goal Mechanobiology
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Mechanobiology
research field
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Mechanobiology Dental Medicine
Core Faculty Members
The Goal of Mechanobiology
Research Center
MRC Lecture Series
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ABOUT US
Message
History
Aim & Scope
Constact Us
PEOPLE
Core Faculty Members
Adjunct Faculty Members
Research Associates & Post-docs
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RESEARCH
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Biomaterials and Interfaces
Nanotherapeutics and Delivery
Stem Cell Engineering
Neural Regeneration
Musculoskeletal Tissue Engineering
Tooth Repair and Dental Materials
Degenerative Diseases
Animal Models and Clinical Studies
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Job Recruitment
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Highlights
News & Story
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Template
BULLENTIN
Medical Research Center
The Goal Mechanobiology
Research Center
Mechanobiology
research field
Research ability of
Mechanobiology Dental Medicine
Core Faculty Members
The Goal of Mechanobiology
Research Center
MRC Lecture Series
Feature Articles
Bioactive Materials (2024) Adaptive immunity of materials: Implications for tissue healing and regeneration
JH Lee*, SJ Shin, JH Lee, JC. Knowles, HH Lee, HW Kim*
Advanced Science (2024) Neural Tissue-Like, not Supraphysiological, Electrical Conductivity Stimulates Neuronal Lineage Specification through Calcium Signaling and Epigenetic Modification
Li YM, Ji Y, Meng YX, Kim YJ, Lee H, Kurian AG, Park JH, Yoon JY, Knowles JC, Choi Y, Kim YS, Yoon BE, Singh RK, Lee HH, Kim HW*, Lee JH*
Advanced Science (2024) Tissue Mechanics and Hedgehog Signaling Crosstalk as a Key Epithelial–Stromal Interplay in Cancer Development
Karunasagara S, Taghizadeh A, Kim SH, Kim SJ, Kim YJ, Taghizadeh M, Kim MY, Oh KY, Lee JH, Kim HS, Hyun J*, Kim HW*
Advanced Science (2024) Targeting Nuclear Mechanics Mitigates the Fibroblast Invasiveness in Pathological Dermal Scars Induced by Matrix Stiffening
Fu X, Taghizadeh A, Taghizadeh M, Li CJ, Lim NK, Lee JH, Kim HS*, Kim HW*
Nano-Micro Letters (2024) Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration
Kurian AG, Singh RK, Sagar V, Lee JH, Kim HW*
Feature Articles @ITREN in 2018~2023 (최근 5년간 출간된 하이라이트 논문 40편)
ITREN
Advanced Science (2023) Cyclic stretch promotes cellular reprogramming process through cytoskeletal-nuclear mechao-coupling...
Park SM, Lee JH*, Ahn GS,..., Shim H*, Kim HW*
Trends in Biotechnology (2023) Advanced materials technologies to unravel mechanobiological phenomena
Kim HS, Taghizadeh A, Taghizadeh M, Kim HW*
Advanced Functional Materials (2023) Coordinated Biophysical Stimulation of MSCs via Electromagnetized Au-Nanofiber Matrix Regulates Cytoskeletal-to-Nuclear Mechanoresponses and Lineage Specification
Singh RK*, Kurian AG, Sagar V, ..., Lee JH*, Kim HW *
Bioactive Materials (2023) Double hits with bioactive nanozyme based on cobalt-doped nanoglass for acute and diabetic wound therapies through anti-inflammatory and pro-angiogenic functions
Mandakhbayar N, Ji Y, ..., Lee JH*, Kim HW*
Materials Today Bio (2023) Multifunctional dendrimer@nanoceria engineered GelMA hydrogel accelerates bone regeneration through orchestrated cellular responses
Kurian AG, Mandakhbayar N, Singh RK*, Lee JH*, Jin G, Kim HW*
Chemical Engineering Journal (2023) Electroconductive and mechano-competent PUCL@CNT nanohybrid scaffolds guiding neuronal specification
Li YM, Patel KD, Han YG, ... Lee JH*, Kim HW*
Biomaterials (2023) Mechano-modulation of T cells for cancer immunotherapy
Hyun J*, Kim SJ, Cho SD, Kim HW*
Progress in Materials Science (2023) Materials-based nanotherapeutics for injured and diseased bone
Lee CS, Sing RK, ... Kim HS*, Lee M*, Kim HW*
Advanced Healthcare Materials (2023) Delivery of Induced Neural Stem Cells Through Mechano-tuned Silk-collagen Hydrogels...
Davaa G, Hong JY, Lee JH,... Hyun JK*, Kim HW*
Biomaterials (2022) Nanoceria-GO-intercalated multicellular spheroids revascularize and salvage critical ischemic limbs through anti-apoptotic...
Bayaraa O, Dashnyam K, Singh RK,...Lee JH, Kim HW*
Matter (2022) Matrix-enabled mechanobiological modulation of osteoimmunology
Jung-Hwan Lee, Jae Hee Park, Jun Hee Lee, Hae-Hyoung Lee, Jonathan C Knowles, Hae-Won Kim
Biomaterials (2022) Chemically-induced osteogenic cells for bone tissue engineering and disease modeling
Yoon JY, Mandakhbayar N, Hyun J, ..., Lee JH*, Leong KW, Kim HW*
Bioactive Materials (2022) Dendritic cell-mimicking scaffolds for ex vivo T cell expansion
Kim HS, Ho TC, ..., Kim HW, Leong KW*
Advanced Healthcare Materials (2022) Mimicking Bone Extracellular Matrix: From BMP-2-Derived Sequences...
Oliver-Cervelló L, Martin-Gómez H, ...,Kim HW, Ginebra MP, Lee JH, Mas-Moruno C*
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ITREN Bulletin-Vol-1 has been published
We are ITREN, join here!
Feature Articles @ITREN in 2018~2023 (최근 5년간 출간된 하이라이트 논문 40편)
Congratulations! Medical Research Center (MRC) Program Granted!
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News & Story
Featured as Cover Picture in Advanced Science
Fibroblasts in pathological dermal scar called Keloid are migrating through highly stiff extracellular matrix made of fibrous collagenous network. Cells mechano-sense the stiff matrix environment, deforming nucleus via downregulating nuclear lamina expression to facilitate migratory ability. This elucidates the mechanism by which fibroblasts within the exceptionally stiff matrix of Keloid tissue manifest invasiveness through nuclear deformation. Furthermore, it underscores potential therapeutic targets in the modulation of nuclear mechanics for the treatment of pathological dermal scars. More details can be found in article number 2308253 by Hye Sung Kim, Hae-Won Kim, and co-workers.
2024-04-18
Featured as Inside Back Cover in Advanced Functional Materials
In article number 2304821, Rajendra K. Singh, Jung-Hwan Lee, Hae-Won Kim, and co-workers demonstrate that biophysical multiple cues coordinated from electromagnetized Au-nanoparticles-decorated polymer nanofiber under electromagnetic fields significantly regulate the adhesion, alignment, proliferation, and lineage commitment of hMSCs. Without the EMF, matrix cues of electrical conductivity and nanodotted fibrous topography accelerate the anchorage and spreading of hMSCs.
2023-12-28
ITREN's year end symposium for year 2023
ITREN members were thrilled to enjoy the year-end celebration, which signaled the successful end of another year that had been full of challenges, setbacks, and successes. Cheers to a year well-done and the excitement of new beginnings!
2023-12-15
ITREN hosts International Symposium for Global Research Development Centers and Global Hub Centers.
2023 International Joint Research Symposium of Excellent Overseas Research Institutions hosted by ITREN was held at the Samjeong Hotel, Seoul on 2023-11-21. The international symposium focusesd on fostering exchange and collaboration for the advancement of cutting-edge science and technology, engaging with world-class research centers. The overarching goal is to enhance international cooperation networks, particularly in the realms of scientific and technological development, as well as industrial technology advancement and commercialization. NEWS HIGHLIGHTS 글로벌 R&D '환골탈태'…연구기간·규모 확 늘린다 | 서울경제 (sedaily.com) '2023 해외우수연구기관 국제공동연구 심포지엄' (newspim.com) 이종호 과기정통부 장관 "글로벌 R&D 최적기···국제협력, 연구비 퍼주기 아니다" - ZDNet korea 전문가들 “글로벌 R&D 강화 모멘텀 놓치지 말아야”-국민일보 (kmib.co.kr)
2023-11-21
Featured as Front Cover Image in Advanced Science
In article number 2303395, Jung-Hwan Lee, Hosup Shim, Hae-Won Kim, co-workers revealed that cyclic stretching of cells during reprogramming process significantly enhanced the efficiency of iPSC production through mechanotransduction molecules along the cytoskeletal-nuclear axis by epigenetic changes. This mechanical cell-engineering aids in mass-production of iPSCs and regenerative medicine. NEWS Highlighted 단국치대 연구진, 세포리포로그래밍 주제로 커버 논문 ‘화제’ (dailydental.co.kr)
2023-11-15
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BULLENTIN
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Lecture Series
145. Song Li (UCLA)
144. Chwee Teck Lim(MBI, Singapore) "Mechanoengineering, mechano-gels/platforms"
143. Kevin chalut(UK cambridge) "Development and stem cells"
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