Feature Articles
Nature Communications (2026) Sprayable nanozyme hydrogel epigenetically remodels inflammation for diabetic wound regeneration
Kurian AG#, Park JH#, ... Lee JH*, Leong KW, Kim HW*
Research (2026) pH-gated antimicrobial hydrogel with conformational adaptation for precision therapeutic release
Kim YJ, Shin SJ, Lee YS, Yang YJ, Lee YJ, Jun SK, Lee HH, Kim HS, Shin US*, Lee JH*
Biomaterials (2026) Mechanobiological engineering strategies for oral and maxillofacial tissue regeneration
Park JH, Sagar V, Leong KW, Kim HW*, Kim HS*
Adv Fib Mater (2026) Jammed Microfiber Inks Enable Aligned 3D Printing for Epigenetic Muscle Regeneration
Youn KI, Park JH, Mandakhbayar N, Taghizadeh M, Jin S, Kim J, Lee JH*, Song KH*
Mechanobiology (2026) Launching Mechanobiology
Hae-Won Kim, Vivek Shenoy
Adv Coll Interf Sci (2026) Bioactive glasses in the new era: Technological advances and targeted therapies
Gupta A, Kurian AG, Jain SK, Singh RK*, Kim HW*
Biomaterials (2026) Regenerative dentistry with multifunctional nanomaterials: Orchestrating immunomodulatory, pro-angiogenic, stem cell activating, and antibacterial responses
Lee H, Lee JH, Kim HS, Lee HH*, Kim HW*
Advanced Science (2025) Temporal Stretch-Induced Nuclear Mechanosensing Coordinates Early Chromatin Accessibility and Genome Protection
Shim HW, Yoon JY, Lee HL, ... Lee JH*, Leong KW, Kim HW*
Bioactive Mater (2025) Bioprinting for drug screening: A path toward reducing animal testing or redefining preclinical research?
H Budharaju, RK Singh, HW Kim*
Trends in Biotechnology (2025), Biomechanics in miniature: microfluidic-based in vitro modeling to decipher mechanobiological phenomena
Hong HJ, Lee NH, Kim HS*, Leong KW, Kim HW*
Cell Reports (2025), Matrix-induced nuclear remodeling and mechano-therapeutics.
Lee JH, Yun YG, Kim HW*
J Nanobiotech (2025) Advanced therapeutic scaffolds of biomimetic periosteum for functional bone regeneration
Gupta A, Kim KW, Kurian AG, Jain SK, Bhattacharya S, Singh RK*, Kim HW*
Bioactive Materials (2025) Mechanosignaling and 3D morphological adaptation of MSCs in response to hydrogel rigidity underpin angiogenic and immunomodulatory efficacy for ischemic injury regeneration
Yun YG , Heo SC , Jung JW , Yeo DH , Shin SJ , Tsogtbaatar K , Hwang YS , Lee JH * , Lee JH * , Kim HW *
ACS Nano (2025) Push-and-Pull Nanotherapeutics for Osteoarthritis with Drug Delivery and Dual Scavenging of Reactive Oxygen Species and Cell-Free DNA
Singh RK*, Mandakhbayar N, Kurian AG, Jain SK, Bhattacharya S, Gupta A, Lee JH, Kim HW*
Bioactive Materials (2025) Single-atom Pt-doped ceria nanozymes mitigate myocardial ischemia reperfusion injury via cardiomyocyte-targeted uptake and suppression of reactive oxygen species
Pu A , Sim WS, Ji YS, Kurian AG, Lee JH , Bui TVA, Lai Y, Hwangbo HS, Sun HH, Kim HW *, Park HJ *, Ban KW *
Materials Horizons (2025) Chondrocyte-mimetic therapeutic microcarriers for synergistic chemo-mechanical signaling in cartilage regeneration
Lee NH #, Zhou Z #, Yoon JY #, Mandakhbayar N, Li CJ, Lee JH, Kim HW *, Kim HS *
Advanced Functional Materials (2025) Eco-Fabricated Nanowave-Textured Implants Drive Microtubule-Assisted Nuclear Mechanotransduction and Chromatin Modification: Biophysical Priming for Osteogenesis and Bone Regeneration
Jeong B , Yoon JY, Ahn JY, Lee BH, Park SM, Kim JH,Bayarkhangai B, Kim YJ, Lee S, Knowles J C, Kim MY, Lee DJ, Rhee SH *, Lee HH *, Kim HW *, Lee JH*
Advanced Science (2025) Matrix-Rigidity Cooperates With Biochemical Cues in M2 Macrophage Activation Through Increased Nuclear Deformation and Chromatin Accessibility
Shin SJ ,Bayarkhangai B, Tsogtbaatar K, Meng YX, Kim SH, Kim YJ, Taghizadeh A, Kim DS, Kim DH, Lee JH *, Hyun JG *, Kim HW *
Biomaterials (2024) Electrically-stimulated cellular and tissue events are coordinated through ion channel-mediated calcium influx and chromatin modifications across the cytosol-nucleus space
Karunasagara S, Bayarkhangai B, Shim HW, Bae H J, Lee H, Taghizadeh A, Ji Y, Mandakhbayar N, Kim HS, Hyun J, Kim TJ, Lee JH*, Kim HW*
Bioactive Materials (2024) Adaptive immunity of materials: Implications for tissue healing and regeneration
JH Lee*, SJ Shin, JH Lee, JC. Knowles, HH Lee, HW Kim*
News & Story
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- ITREN-MRC Conference & Workshop Summer 2026
- Conference & Workshop, Summer 2026 14-16 June 2026 · High1 Resort, Jeongseon, Gangwon-do The Institute of Tissue Regeneration Engineering (ITREN) held its 2026 Summer Conference and Workshop from 14 to 16 June at High1 Resort in Jeongseon, Gangwon-do, jointly organized with the Mechanobiology Dental Medicine Research Center (MRC). Over three days, faculty members and graduate students presented current research across mechanobiology, tumor microenvironments, immune signaling and tissue regeneration. The program also included a session on research methodology, followed by a field excursion in the Jeongseon area. From the sessions + Glioblastoma Glioblastoma A growing brain tumor does more than send chemical signals to the immune cells around it. It also reshapes the physical space those cells move through. This session looked at how mechanical cues from the tumor matrix combine with tumor-derived molecular signals to steer the behavior of microglia, and what that combination means for how a tumor is policed from within. + Atopic dermatitis Atopic dermatitis Inflamed skin becomes measurably stiffer, and that stiffening is not only a symptom. The talk examined how changes in extracellular matrix stiffness feed into mast cell activation and mechanosignaling, treating the physical state of the tissue as an active contributor to the atopic dermatitis microenvironment rather than a by-product of it. + Research practice Research practice A step back from results to method. Good experiments answer what happened; mechanistic thinking asks why, how, and under which conditions the answer holds. Drawn from the speaker's own doctoral work, the session traced how a set of observations turns into an explanation, and where that transition most often goes wrong. Around the workshop Outside the sessions, along the Jeongseon river. ITREN members at the institute in Cheonan. .itr26{line-height:1.75;color:#222;} .itr26 *{box-sizing:border-box;} .itr26-hero-img{transform:scale(1.06);animation:itr26zoom 18s ease-out forwards;} @keyframes itr26zoom{to{transform:scale(1);}} .itr26-hero-sh{background:linear-gradient(to top,rgba(8,25,42,.86),rgba(8,25,42,0));} .itr26-rv{opacity:0;transform:translateY(22px);transition:opacity .7s ease,transform .7s ease;} .itr26-rv.on{opacity:1;transform:none;} .itr26-head{display:flex;align-items:center;gap:14px;margin:0 0 18px;} .itr26-head span{font-size:17px;letter-spacing:1.2px;text-transform:uppercase;color:#0f2f4f;font-weight:700;white-space:nowrap;} .itr26-head i{flex:1;height:1px;background:#dfe6ec;display:block;} .itr26-grid{display:flex;flex-wrap:wrap;gap:12px;margin:0 0 30px;} .itr26-grid>*{flex:1 1 210px;} .itr26-flip{perspective:1200px;cursor:pointer;} .itr26-inner{transition:transform .75s cubic-bezier(.4,.2,.2,1);transform-style:preserve-3d;} .itr26-flip.f .itr26-inner{transform:rotateY(180deg);} .itr26-face{backface-visibility:hidden;-webkit-backface-visibility:hidden;} .itr26-fl{position:absolute;left:0;right:0;bottom:0;padding:34px 14px 13px;background:linear-gradient(to top,rgba(8,25,42,.92),rgba(8,25,42,0));color:#fff;font-size:14.5px;font-weight:600;line-height:1.4;} .itr26-badge{position:absolute;top:10px;right:11px;width:26px;height:26px;border-radius:50%;background:rgba(255,255,255,.94);color:#0f2f4f;font:700 15px/26px Arial,sans-serif;text-align:center;z-index:2;transition:transform .45s ease;} .itr26-badge:after{content:"";position:absolute;top:-5px;left:-5px;right:-5px;bottom:-5px;border-radius:50%;border:2px solid rgba(255,255,255,.75);animation:itr26pulse 2.6s ease-out infinite;} @keyframes itr26pulse{0%{transform:scale(.85);opacity:.9;}70%{transform:scale(1.35);opacity:0;}100%{opacity:0;}} .itr26-flip:hover .itr26-badge,.itr26-flip.f .itr26-badge{transform:rotate(135deg);} .itr26-flip.f .itr26-badge:after{animation:none;opacity:0;} .itr26-back{transform:rotateY(180deg);} .itr26-back h4{margin:0 0 9px;font-size:11px;letter-spacing:2px;text-transform:uppercase;color:#7cc0ec;font-weight:700;} .itr26-back p{margin:0;font-size:13px;line-height:1.62;} .itr26-ph{position:relative;overflow:hidden;border-radius:5px;cursor:zoom-in;} .itr26-ph img{transition:transform .6s ease;} .itr26-ph:hover img{transform:scale(1.05);} .itr26-cap{margin:9px 0 0;font-size:13px;line-height:1.5;color:#777;text-align:center;} .itr26-lb{position:fixed;top:0;left:0;right:0;bottom:0;background:rgba(6,15,24,.94);display:none;align-items:center;justify-content:center;z-index:99999;padding:24px;cursor:zoom-out;} .itr26-lb.on{display:flex;} .itr26-lb img{max-width:96%;max-height:92%;border-radius:4px;} @media (prefers-reduced-motion:reduce){.itr26-hero-img{animation:none;transform:none;}.itr26-rv{opacity:1;transform:none;}.itr26-badge:after{animation:none;}} @media (max-width:640px){.itr26-hero-img{padding-top:56%;}.itr26-hero-t{font-size:21px;}.itr26-inner{padding-top:78%;}} (function(){ var root=document.querySelector('.itr26'); if(!root)return; root.querySelectorAll('.itr26-flip').forEach(function(c){ c.addEventListener('click',function(){c.classList.toggle('f');}); }); var lb=root.querySelector('.itr26-lb'),lbi=lb.querySelector('img'); root.querySelectorAll('.itr26-ph img').forEach(function(im){ im.parentNode.addEventListener('click',function(){lbi.src=im.src;lb.classList.add('on');}); }); lb.addEventListener('click',function(){lb.classList.remove('on');}); document.addEventListener('keydown',function(e){if(e.key==='Escape')lb.classList.remove('on');}); var rv=root.querySelectorAll('.itr26-rv'); if('IntersectionObserver' in window){ var io=new IntersectionObserver(function(es){es.forEach(function(e){if(e.isIntersecting){e.target.classList.add('on');io.unobserve(e.target);}});},{threshold:.12}); rv.forEach(function(e){io.observe(e);}); }else{rv.forEach(function(e){e.classList.add('on');});} })();
- 2026-09-03
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- ITREN Key Lecture: Prof. Konstantinos Konstantopoulos (Johns Hopkins University) on Cancer Cell Mechanobiology
- Key Lecture Cancer Cell Mechanobiology Prof. Konstantinos Konstantopoulos · Johns Hopkins University Prof. Konstantinos Konstantopoulos of Johns Hopkins University visited ITREN to deliver a Key Lecture on Cancer Cell Mechanobiology, showing how physical and chemical cues in the tumor microenvironment guide cancer cell migration and metastasis. DateMonday, 27 April 2026 VenueRoom 524, Pharmacy Building HostITREN, Dankook University Lecture content ITREN faculty and graduate students at the Key Lecture in Room 524, Pharmacy Building. Confinement, stiffness, viscoelasticity, acidosis and hypoxia as combined drivers of cell behavior. .itrkl{font-family:'Helvetica Neue',Arial,'Malgun Gothic',sans-serif;color:#1a1a1a;line-height:1.75;width:100%;margin:0;} *:has(> .itrkl){max-width:none !important;width:auto !important;} .itrkl *{box-sizing:border-box;} .itrkl-heroimg{transform:scale(1.07);animation:itrklzoom 20s ease-out forwards;} @keyframes itrklzoom{to{transform:scale(1);}} .itrkl-herosh{background:linear-gradient(to top,rgba(8,20,32,.94),rgba(8,20,32,.4) 60%,rgba(8,20,32,0));} .itrkl-herok{font-size:12px;letter-spacing:3px;text-transform:uppercase;color:#8fd0f5;font-weight:700;} .itrkl-herot{font-size:34px;line-height:1.2;color:#fff;font-weight:700;} .itrkl-herom{font-size:17px;color:#d3e5f2;} .itrkl-rv{opacity:0;transform:translateY(20px);transition:opacity .7s ease,transform .7s ease;} .itrkl-rv.on{opacity:1;transform:none;} .itrkl-facts{display:flex;flex-wrap:wrap;gap:10px;margin:0 0 40px;} .itrkl-fact{flex:1 1 200px;background:#f4f7fa;border-left:3px solid #1f6fb2;padding:14px 16px;} .itrkl-fact span{display:block;font-size:12px;letter-spacing:1.4px;text-transform:uppercase;color:#7b8794;font-weight:700;margin-bottom:3px;} .itrkl-fact strong{display:block;font-size:15.5px;color:#16222f;font-weight:600;line-height:1.45;} .itrkl-head{display:flex;align-items:center;gap:14px;margin:0 0 18px;} .itrkl-head span{font-size:17px;letter-spacing:1.2px;text-transform:uppercase;color:#0f2f4f;font-weight:700;white-space:nowrap;} .itrkl-head i{flex:1;height:1px;background:#dfe6ec;display:block;} .itrkl-grid{display:flex;flex-wrap:wrap;gap:14px;margin:0;} .itrkl-grid>*{flex:1 1 280px;} .itrkl-ph{cursor:zoom-in;} .itrkl-ph img{transition:transform .7s ease;} .itrkl-ph:hover img{transform:scale(1.06);} .itrkl-cap{position:absolute;left:0;right:0;bottom:0;background:linear-gradient(to top,rgba(8,20,32,.94),rgba(8,20,32,0));color:#fff;font-size:17px;line-height:1.55;padding:62px 20px 17px;} .itrkl-lb{position:fixed;top:0;left:0;right:0;bottom:0;background:rgba(6,15,24,.94);display:none;align-items:center;justify-content:center;z-index:99999;padding:24px;cursor:zoom-out;} .itrkl-lb.on{display:flex;} .itrkl-lb img{max-width:96%;max-height:92%;border-radius:4px;} @media (prefers-reduced-motion:reduce){.itrkl-heroimg{animation:none;transform:none;}.itrkl-rv{opacity:1;transform:none;}} @media (max-width:640px){.itrkl-herot{font-size:23px;}.itrkl-herom{font-size:15px;}.itrkl-cap{font-size:15px;padding:50px 14px 13px;}.itrkl-herosh{padding:56px 18px 16px;}} (function(){ var r=document.querySelector('.itrkl'); if(!r)return; var lb=r.querySelector('.itrkl-lb'),lbi=lb.querySelector('img'); r.querySelectorAll('.itrkl-ph').forEach(function(p){ p.addEventListener('click',function(){var im=p.querySelector('img');if(im){lbi.src=im.src;lb.classList.add('on');}}); }); lb.addEventListener('click',function(){lb.classList.remove('on');}); document.addEventListener('keydown',function(e){if(e.key==='Escape')lb.classList.remove('on');}); var rv=r.querySelectorAll('.itrkl-rv'); if('IntersectionObserver' in window){ var io=new IntersectionObserver(function(es){es.forEach(function(e){if(e.isIntersecting){e.target.classList.add('on');io.unobserve(e.target);}});},{threshold:.12}); rv.forEach(function(e){io.observe(e);}); }else{rv.forEach(function(e){e.classList.add('on');});} })();
- 2026-09-01
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- (2026.06) Journal of Tissue Engineering Reports Impact Factor of 10.1
- 2026 Journal Metrics Update · Institute of Tissue Regeneration Engineering 10.1 Impact Factor 8.2 5-Year IF 3rd Category Rank ITREN Tissue Engineering ITREN's Journal of Tissue Engineering Impact Factor Is Now 10.1 Now ranked 3rd in the Cell and Tissue Engineering category. Journal of Tissue Engineering publishes peer-reviewed research on tissue engineering and its clinical application, spanning cell biology, biophysics, materials science, and biomaterials. Its scope runs from the basic biology of stem and progenitor cells through bioreactor-based three-dimensional culture to preclinical models and clinical trials, with the broader aim of restoring or improving tissue and organ function. Editors-in-Chief View Profile Hae-Won Kim Director of ITREN Dankook University View Profile Jonathan C. Knowles University College London View Journal Site → document.getElementById('jte-wrap').style.opacity = '1'; var jteMq = window.matchMedia('(max-width:480px)'); function jteHandleMobile(e) { var panel = document.getElementById('jte-stats-panel'); var ringWrap = document.getElementById('jte-ring-wrap'); var ringSvg = document.getElementById('jte-ring-svg'); var ringLabel = document.getElementById('jte-ring-label'); if(e.matches) { panel.style.height = 'auto'; panel.style.minHeight = '160px'; panel.style.padding = '20px 16px'; ringWrap.style.width = '110px'; ringWrap.style.height = '110px'; ringSvg.style.width = '110px'; ringSvg.style.height = '110px'; ringLabel.style.width = '110px'; ringLabel.style.height = '110px'; document.getElementById('jte-count-if').style.fontSize = '24px'; } else { panel.style.height = '160px'; panel.style.minHeight = ''; panel.style.padding = '0 28px'; ringWrap.style.width = '150px'; ringWrap.style.height = '150px'; ringSvg.style.width = '150px'; ringSvg.style.height = '150px'; ringLabel.style.width = '150px'; ringLabel.style.height = '150px'; document.getElementById('jte-count-if').style.fontSize = '34px'; } } jteHandleMobile(jteMq); jteMq.addListener(jteHandleMobile); (function() { var bg = document.getElementById('jte-cover-bg'); var startTime = null; function drift(timestamp) { if(!startTime) startTime = timestamp; var elapsed = (timestamp - startTime) / 1000; var cycle = 18; var t = (elapsed % cycle) / cycle; var wave = Math.sin(t * Math.PI * 2); var scale = 1.04 + wave * 0.025; var x = wave * 1.5; var y = Math.cos(t * Math.PI * 2) * 1.2; bg.style.transform = 'scale(' + scale + ') translate(' + x + '%, ' + y + '%)'; requestAnimationFrame(drift); } requestAnimationFrame(drift); })(); var jteStatsTriggered = false; function jteAnimateStats() { if(jteStatsTriggered) return; var wrap = document.getElementById('jte-wrap'); var rect = wrap.getBoundingClientRect(); var windowHeight = window.innerHeight || document.documentElement.clientHeight; if(rect.top > windowHeight * 0.85) return; jteStatsTriggered = true; var ring = document.getElementById('jte-ring'); var circumference = 314.159; var targetOffset = circumference * (1 - 0.81); var startTime = null; var duration = 1400; function step(timestamp) { if(!startTime) startTime = timestamp; var progress = Math.min((timestamp - startTime) / duration, 1); var eased = 1 - Math.pow(1 - progress, 3); ring.setAttribute('stroke-dashoffset', circumference - (circumference - targetOffset) * eased); document.getElementById('jte-count-if').textContent = (10.1 * eased).toFixed(1); document.getElementById('jte-count-5yr').textContent = (8.2 * eased).toFixed(1); if(progress
- 2026-06-23
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- (2026.03) Prof. Hae-Won Kim, Director of ITREN's New Book Published
- 2026 New Book Release · Institute of Tissue Regeneration Engineering 12 Chapters 01 Epigenetics & Cell Reprogramming 02 Stem Cells & Organoids 03 Microbiome Revolution 04 CRISPR & Gene Therapy 05 Synthetic Biology 06 Precision Medicine & Cancer 07 mRNA Vaccines & Nanomedicine 08 Tissue Engineering & Regeneration 09 3D Bioprinting & Artificial Organs 10 Brain-Computer Interfaces 11 Surgical Robotics 12 Wearable Healthcare & AI Tap again to close Tap to see chapters ITREN Biomedical Engineering Biomedical Engineering Stories: Changing the Future From genetics to robotic surgery: 12 innovations in life science and medical technology Drawing on 25 years of research experience, Prof. Kim presents an accessible guide to 12 breakthrough biomedical technologies, covering how laboratory discoveries move from the bench to the clinic and into everyday life. View Profile Prof. Hae-Won Kim Director, ITREN Dankook University Get your copy on YES24 → var mq = window.matchMedia('(max-width:600px)'); function handleMobile(e) { var body = document.getElementById('bk-body'); var cover = document.getElementById('bk-cover'); if(e.matches) { body.style.flexDirection = 'column'; cover.style.width = '100%'; cover.style.minWidth = '100%'; cover.style.minHeight = '340px'; cover.style.borderRight = 'none'; cover.style.borderBottom = '1px solid #e5e7eb'; } else { body.style.flexDirection = 'row'; cover.style.width = '300px'; cover.style.minWidth = '300px'; cover.style.minHeight = '440px'; cover.style.borderRight = '1px solid #e5e7eb'; cover.style.borderBottom = 'none'; } } handleMobile(mq); mq.addListener(handleMobile); var profTriggered = false; window.addEventListener('scroll', function() { if(profTriggered) return; var profWrap = document.getElementById('prof-wrap'); if(!profWrap) return; var rect = profWrap.getBoundingClientRect(); var windowHeight = window.innerHeight || document.documentElement.clientHeight; if(rect.top
- 2026-05-13
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- Featured as Back Cover in Advanced Science
- Temporal Stretch-Induced Nuclear Mechanosensing Cells subjected to temporal mild stretching rapidly activate their nuclear mechanosensing machinery, leading to changes in nuclear mechanics and epigenetic states that upregulate genes involved in genome protection and cellular plasticity. More details can be found in the Research Article by Jung-Hwan Lee, Kam W. Leong, Hae-Won Kim, and co-workers (DOI: 10.1002/advs.202510554).
- 2026-02-09
Lecture Series
- 153. University of California, Timothy L. Downing, Biophysical Regulation of Cell Fate, from ECM to Nuclear Chromatin
- 152. Victer Chang Cardiac Research Institute, Charles D Cox, Mechanobiology and mechanical interaction of cells and tissues
- 151. Pennsylvania University, Dennis Discher, Mechanobiology and Immune Modulation in Cancer